The Biochemistry of Translational Medicine

BCH2104H

This course will focus on reviewing scientific articles that use biochemistry and/or cell biology to help better understand human diseases. Emphasis will be on published scholarly work that provides examples of translational medicine or “bench-to-bedside” approach, which aims to expedite the discovery of new diagnostics and treatments.

– The first session will be an intro by both of us (~1h) followed by a discussion led by us about a paper (~1h).

– The intro will include some tips on how to present an article, etc.

– The other sessions will be 2 x 1 h sessions where one student presents a recent paper that provides an exciting example of an application of biochemistry to translational medicine (a second student will present another article during the second hour).

– Each student will be free to choose an article themselves or use one from the bank of articles provided by us (typically a very recent article published in of-of the top journals, such as Cell, Science, Nature, Nat Med, Nat Genetics, JCI, Sci Translat Med, etc.).

– Each student will also have to provide a short write-up (max 250 words) about the article presented that would be an abstract that could be read by a layperson (i.e., grade 7-8 education) + a relevant title. This is an important exercise because it is required for most grants that anyone submits.

– The format delineated above may need to be slightly amended depending on the number of students who end up enrolling for the class and do not withdraw.

Course Next Offered

Fall 2025

Course Time and Location

Start Date: TBC
End Date: TBC
Time:

Enrollment Limit

Yes — 10

Method of Student Evaluation

Marks will be derived from:
- journal club presentation (70%)
- participation in other students’ presentations (20%)
- lay abstract (10%)

Coordinator

Mathieu Lemaire

Mathieu Lemaire

Cell Biology Department
Peter Gilgan Centre For Research and Learning
SickKids Research Institute
686 Bay Street, room 19.9704

416-813-7654 ext. 309419
mathieu.lemaire@sickkids.ca

Aleixo Muise

Aleixo Muise

PGCRL Tower
19.9400, J-Me
72 Elm Street
416-813-7735 or 416-813-5216
aleixo.muise@sickkids.ca

Last Updated 28 July 2025